Structure of PDB 7t96 Chain A

Receptor sequence
>7t96A (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
EVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLI
IGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDR
YFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV
EDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKPPS
REKKVTRTILAILLAFIITWAPYNVMVLINTPCIPNTVWTIGYWLCYINS
TINPACYALCNATFKKTFKHLLMC
3D structure
PDB7t96 Cryo-EM structure of S2 state ACh-bound M2R-Go signaling complex with a PAM
ChainA
Resolution3.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACH A D103 Y104 S107 W400 Y403 Y426 Y430 D82 Y83 S86 W220 Y223 Y243 Y247
BS02 2CU A Y80 Y177 F181 N410 T423 Y426 Y59 Y156 F160 N230 T240 Y243
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0016907 G protein-coupled acetylcholine receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7t96, PDBe:7t96, PDBj:7t96
PDBsum7t96
PubMed36690613
UniProtP08172|ACM2_HUMAN Muscarinic acetylcholine receptor M2 (Gene Name=CHRM2)

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