Structure of PDB 7t6f Chain A

Receptor sequence
>7t6fA (length=1045) Species: 10090 (Mus musculus) [Search protein sequence]
PEPGVEVTFYLLDREPLRLGSGEYTAEELCIRAAQECSISPLCHNLFALY
DESTKLWYAPNRIITVDDKTSLRLHYRMRFYFTNWHGTNDNEQSVWRHSP
KEATPLLDASSLEYLFAQGQYDLIKCLAPIRDPKTEQDGHDIENECLGMA
VLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNV
FKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLI
SSENELSRCHSNDSGNVLYEVMVTGNLGIQWRQKPNEEWNNFSYFPEITH
IVIKESVVSINKQDNKNMELKLSSREEALSFVSLVDGYFRLTADAHHYLC
TDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDN
ILMTVTKQFKNFQIEVQKGRYSLHGSMDHFPSLRDLMNHLKKQILRTDNI
SFVLKRCCQPKPREISNLLVATKKAQEWQPVYSMSQLSFDRILKKDIIQG
EHLGRGTRTHIYSGTLLDYEKKIKVILKVLDPSHRDISLAFFEAASMMRQ
VSHKHIVYLYGVCFRDVENIMVEEFVEGGPLDLFMHRKSDALTTPWKFKV
AKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLSDPGIPV
SVLTRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPL
KDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRD
INKLEEQNPDIVTEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDN
TGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGN
GIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAIQICKGMDYLGSRQYV
HRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAP
ECLIQCKFYIASDVWSFGVTLHELLTYCDSDFSPMALFLMTVTRLVNTLK
EGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTTFQNLIEGFEALLK
3D structure
PDB7t6f Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation.
ChainA
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADN A V669 L720 V576 L627
BS02 ADP A E882 G883 E956 F957 L958 D1020 E783 G784 E857 F858 L859 D921
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005856 cytoskeleton
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7t6f, PDBe:7t6f, PDBj:7t6f
PDBsum7t6f
PubMed35271300
UniProtP52332|JAK1_MOUSE Tyrosine-protein kinase JAK1 (Gene Name=Jak1)

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