Structure of PDB 7t5k Chain A

Receptor sequence
>7t5kA (length=335) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMG
LTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLF
RLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQG
KDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQ
NDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDR
SLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSV
IAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI
3D structure
PDB7t5k Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.5.2: dihydroorotate dehydrogenase (quinone).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN A A62 G63 K66 T86 N111 N172 K217 N246 S267 G268 V295 G296 G297 Y318 S319 A61 G62 K65 T85 N110 N171 K216 N245 S266 G267 V294 G295 G296 Y317 S318
BS02 HQO A Y3 F11 H19 T22 L100 R102 F321 I322 Y2 F10 H18 T21 L99 R101 F320 I321
Gene Ontology
Molecular Function
GO:0004152 dihydroorotate dehydrogenase activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0106430 dihydroorotate dehydrogenase (quinone) activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0009220 pyrimidine ribonucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7t5k, PDBe:7t5k, PDBj:7t5k
PDBsum7t5k
PubMed35441142
UniProtP0A7E1|PYRD_ECOLI Dihydroorotate dehydrogenase (quinone) (Gene Name=pyrD)

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