Structure of PDB 7t4t Chain A

Receptor sequence
>7t4tA (length=454) Species: 9606 (Homo sapiens) [Search protein sequence]
STGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQG
ARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRT
ANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFF
ANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQ
QEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRD
RGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVD
FGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELL
TGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSER
LGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSW
DIDF
3D structure
PDB7t4t Selective small molecule activation of PKG1alpha: structure and function
ChainA
Resolution2.08 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.12: cGMP-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PCG A I264 V283 L296 R297 F305 G306 E307 K308 A309 R316 T317 E355 I47 V66 L79 R80 F88 G89 E90 K91 A92 R99 T100 E138
BS02 ATP A G382 G384 V389 A403 K405 E454 C456 E460 I506 F664 G165 G167 V172 A186 K188 E237 C239 E243 I289 F447
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004692 cGMP-dependent protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7t4t, PDBe:7t4t, PDBj:7t4t
PDBsum7t4t
PubMed
UniProtQ13976|KGP1_HUMAN cGMP-dependent protein kinase 1 (Gene Name=PRKG1)

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