Structure of PDB 7t3n Chain A

Receptor sequence
>7t3nA (length=452) Species: 10116 (Rattus norvegicus) [Search protein sequence]
LCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGG
KVIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAA
ILLTSTLNMLIPSAARVHYGCVIFVQILQGLVQGVTYPACHGIWSKWAPP
LERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYM
FWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFKTPWRKFFT
SMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLV
MTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHT
RGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGM
VCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYALFASGEKQPWADP
EE
3D structure
PDB7t3n Substrate Recognition, Directional Flux, and Allostery in a Synaptic Vesicle Glutamate Transporter
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C5B A Y135 Y195 Y223 R322 F326 Y327 Y77 Y137 Y165 R264 F268 Y269
BS02 I7Y A R70 Y71 E210 G221 R12 Y13 E152 G163
Gene Ontology
Molecular Function
GO:0005254 chloride channel activity
GO:0005313 L-glutamate transmembrane transporter activity
GO:0005326 neurotransmitter transmembrane transporter activity
GO:0005436 sodium:phosphate symporter activity
GO:0015293 symporter activity
GO:0015297 antiporter activity
GO:0015386 potassium:proton antiporter activity
GO:0022857 transmembrane transporter activity
GO:0140787 phosphate ion uniporter activity
GO:0140788 L-glutamate uniporter activity
Biological Process
GO:0001504 neurotransmitter uptake
GO:0003407 neural retina development
GO:0006814 sodium ion transport
GO:0006817 phosphate ion transport
GO:0006820 monoatomic anion transport
GO:0006821 chloride transport
GO:0006836 neurotransmitter transport
GO:0015813 L-glutamate transmembrane transport
GO:0021766 hippocampus development
GO:0034220 monoatomic ion transmembrane transport
GO:0035249 synaptic transmission, glutamatergic
GO:0035725 sodium ion transmembrane transport
GO:0044341 sodium-dependent phosphate transport
GO:0050803 regulation of synapse structure or activity
GO:0051938 L-glutamate import
GO:0055062 phosphate ion homeostasis
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
GO:0098700 neurotransmitter loading into synaptic vesicle
GO:1902476 chloride transmembrane transport
GO:1902600 proton transmembrane transport
GO:1990384 hyaloid vascular plexus regression
Cellular Component
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0030672 synaptic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0034707 chloride channel complex
GO:0043005 neuron projection
GO:0045202 synapse
GO:0060076 excitatory synapse
GO:0098793 presynapse
GO:1990030 pericellular basket

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Cellular Component
External links
PDB RCSB:7t3n, PDBe:7t3n, PDBj:7t3n
PDBsum7t3n
PubMed
UniProtQ9JI12|VGLU2_RAT Vesicular glutamate transporter 2 (Gene Name=Slc17a6)

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