Structure of PDB 7t37 Chain A

Receptor sequence
>7t37A (length=619) Species: 10116 (Rattus norvegicus) [Search protein sequence]
EPPPMESPFQREDRNSPDRFDRDRLFSVVSRGVPEELTGLLEYLRWNSKY
LTDSAYTEGSTGKTCLMKAVLNLQDGVNACIMPLLQIDKDSGNPKLLVNA
QCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGT
CFYFGELPLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVM
IADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNHQGLTPLKLAAKE
GKIEIFRHILQREFSGPYQPLSRKFTEWCYGPVRVSLYDLSSVDSWEKNS
VLEIIAFHCKSPNRHRMVVLEPLNKLLQEKWDRLVSRFFFNFACYLVYMF
IFTVVAYHQPSLFGESMLLLGHILILLGGIYLLLGQLWYFWRRRFMDSYF
EILFLLQALLTVLSQVLRFMETEWYLPLLVLSLVLGWLNLLYYTRGFQHT
GIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSREARAPYRSILDA
SLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVLLTYVLLLNMLIALMS
ETVNHVADNSWSIWKLQKAISVLEMENGYWWCRRKKHREGRLLKVGTPDE
RWCFRVEEVNWAAWEKTLP
3D structure
PDB7t37 Structural insights into TRPV2 activation by small molecules.
ChainA
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P0T A L537 F540 L541 M640 L465 F468 L469 M544
BS02 FZ4 A H521 T522 H449 T450
BS03 FZ4 A R539 L542 R467 L470
BS04 P0T A L631 V635 L535 V539
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006915 apoptotic process
GO:0008285 negative regulation of cell population proliferation
GO:0009266 response to temperature stimulus
GO:0045773 positive regulation of axon extension
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0090280 positive regulation of calcium ion import
GO:0120162 positive regulation of cold-induced thermogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030424 axon
GO:0032584 growth cone membrane
GO:0042470 melanosome
GO:0044295 axonal growth cone
GO:0044297 cell body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7t37, PDBe:7t37, PDBj:7t37
PDBsum7t37
PubMed35484159
UniProtQ9WUD2|TRPV2_RAT Transient receptor potential cation channel subfamily V member 2 (Gene Name=Trpv2)

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