Structure of PDB 7t1i Chain A

Receptor sequence
>7t1iA (length=324) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
QEISYNCDYGDNTFNLAIDIGGTLAKVVFSPIHSNRLMFYTIETEKIDKF
MELLHSIIKEHNNGCYRMTHIIATGGGAFKFYDLLYENFPQIKGISRFEE
MEGLIHGLDFFIHEIPDEVFTYNDQDGERIIPTKAIYPYLLVNIGSGVSI
LKVTEPNNFSRVGGSSLGGGTLWGLLSLITGAQTYDQMLDWAQEGDNSSV
DMLVGDIYGTDYNKIGLKSSAIASSFGKVFQNIEKNNGQMFKNPDICKSL
LFAISNNIGQIAYLQAKINNIQNIYFGGSYTRGHLTTMNTLSYAINFWSQ
GSKQAFFLKHEGYLGAMGAFLSAS
3D structure
PDB7t1i High-resolution crystal structure and chemical screening reveal pantothenate kinase as a new target for antifungal development.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E4C A V160 S161 R173 G176 S177 V148 S149 R161 G164 S165
BS02 E4C A Y220 L229 I234 A235 F330 W331 Y208 L217 I222 A223 F297 W298
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0008204 ergosterol metabolic process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7t1i, PDBe:7t1i, PDBj:7t1i
PDBsum7t1i
PubMed36167065
UniProtQ04430|PANK_YEAST Pantothenate kinase CAB1 (Gene Name=CAB1)

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