Structure of PDB 7t1h Chain A

Receptor sequence
>7t1hA (length=342) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
QEISYNCDYGDNTFNLAIDIGGTLAKVVFSPIHSNRLMFYTIETEKIDKF
MELLHSIIKEHNNGCYRMTHIIATGGGAFKFYDLLYENFPQIKGISRFEE
MEGLIHGLDFFIHEIPDEVFTYNDQDGERIIPTSSGTMDSKAIYPYLLVN
IGSGVSILKVTEPNNFSRVGGSSLGGGTLWGLLSLITGAQTYDQMLDWAQ
EGDNSSVDMLVGDIYGTDYIGLKSSAIASSFGKVFQENKLYSSHESIEKN
NGQMFKNPDICKSLLFAISNNIGQIAYLQAKINNIQNIYFGGSYTRGHLT
TMNTLSYAINFWSQGSKQAFFLKHEGYLGAMGAFLSASRHSS
3D structure
PDB7t1h High-resolution crystal structure and chemical screening reveal pantothenate kinase as a new target for antifungal development.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E5B A I227 G228 L229 I234 A235 F330 W331 I220 G221 L222 I227 A228 F311 W312
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0008204 ergosterol metabolic process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7t1h, PDBe:7t1h, PDBj:7t1h
PDBsum7t1h
PubMed36167065
UniProtQ04430|PANK_YEAST Pantothenate kinase CAB1 (Gene Name=CAB1)

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