Structure of PDB 7t1g Chain A

Receptor sequence
>7t1gA (length=339) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
QEISYNCDYGDNTFNLAIDIGGTLAKVVFSPIHSNRLMFYTIETEKIDKF
MELLHSIIKEHNNGCYRMTHIIATGGGAFKFYDLLYENFPQIKGISRFEE
MEGLIHGLDFFIHEIPDEVFTYNDQDGERIIPTSSDSKAIYPYLLVNIGS
GVSILKVTEPNNFSRVGGSSLGGGTLWGLLSLITGAQTYDQMLDWAQEGD
NSSVDMLVGDIYGTDYNKIGLKSSAIASSFGKVFQNKLYSSHESIEKNNG
QMFKNPDICKSLLFAISNNIGQIAYLQAKINNIQNIYFGGSYTRGHLTTM
NTLSYAINFWSQGSKQAFFLKHEGYLGAMGAFLSASRHS
3D structure
PDB7t1g High-resolution crystal structure and chemical screening reveal pantothenate kinase as a new target for antifungal development.
ChainA
Resolution2.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E66 A Y220 Y224 L229 I234 A235 F330 W331 Y212 Y216 L221 I226 A227 F309 W310
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0008204 ergosterol metabolic process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7t1g, PDBe:7t1g, PDBj:7t1g
PDBsum7t1g
PubMed36167065
UniProtQ04430|PANK_YEAST Pantothenate kinase CAB1 (Gene Name=CAB1)

[Back to BioLiP]