Structure of PDB 7t0v Chain A

Receptor sequence

>7t0vA (length=568) Species: 209285 (Thermochaetoides thermophila)

RTPPTKVSILDIAGVDDTLQRLLKEVWFPLRGGEACEKMGYRYDNGVLLH
GPSGCGKTTLAHAIAGSIGVAFIPVSAPSVIGGTSGESEKNIRDVFDEAI
RLAPCLIFLDQIDAIAGRRESANKGMESRIVAEIMNGMDRIRQNTPLGKN
VVVLAATNRPEFLDPAIRRRFSVEIDMGMPSERAREQILRSLTRDLSLAD
DINFKELAKMTPGYVGSDLQYVVKAAVSESFQANIDSLLAQARAKHPVSQ
PQRDWLLLEAHRDEEVSWPSTKITMEQFRKAVSLVQPASKREGFSTIPDT
TWSHVGALEDVRKKLEMSIIGPIKNPELFTRVGIKPAAGILLWGPPGCGK
TLVAKAVANESKANFISIKGPELLNKYVGESERAVRQLFSRAKSSAPCIL
FFDQMDALVPRRDDSLSDASARVVNTLLTELDGVGDRSGIYVIGATNRPD
MIDEAIRRPGRLGTSIYVGLPSAEDRVKILKTLYRNTVTTDADLEKVALD
LRCTGFSGADLGNLMQAAAQACLERVYTQRQQKRKEEEIEPVITMEDWEK
ALNEVKPSVKDPEKYMHS

3D structure

• PDB: 7t0v Communication network within the essential AAA-ATPase Rix7 drives ribosome assembly.
• Chain: A
• Resolution: 3.67 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	K574 Y575	K376 Y377
BS02	ATP	A	G504 P544 G545 C546 G547 K548 T549 L550 N645 I677 L681 G733 A734	G306 P346 G347 C348 G349 K350 T351 L352 N447 I479 L483 G508 A509
BS03	ATP	A	I204 A205 S245 G246 C247 G248 K249 T250 T251 I380 L384 G408 S409	I12 A13 S53 G54 C55 G56 K57 T58 T59 I188 L192 G216 S217

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:1990275 preribosome binding

Biological Process

• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:7t0v, PDBe:7t0v, PDBj:7t0v
• PDBsum: 7t0v
• PubMed: 36090660
• UniProt: G0RZG1