Structure of PDB 7szb Chain A

Receptor sequence
>7szbA (length=232) Species: 9606 (Homo sapiens) [Search protein sequence]
EPAPEAEALAAARERSSRFLSGLELVKQGAEARVFRGRFQGRAAVIKHRF
PKGYRHPALEARLGRRRTVQEARALLRCRRAGISAPVVFFVDYASNCLYM
EEIEGSVTVRDYIQSTMETEKTPQGLSNLAKTIGQVLARMHDEDLIHGDL
TTSNMLLKPPLEQLNIVLIDFGLSFISALPEDKGVDLYVLEKAFLSTHPN
TETVFEAFLKSYSTSSKKARPVLKKLDEVRLR
3D structure
PDB7szb Crystal Structure Analysis of human PRPK complex with a compound
ChainA
Resolution2.02 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.6.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DQ4 A V58 M113 E115 I116 S119 I182 V45 M100 E102 I103 S106 I169
Gene Ontology
Molecular Function
GO:0002039 p53 binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0044024 histone H2AS1 kinase activity
GO:0106310 protein serine kinase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006468 protein phosphorylation
GO:0008033 tRNA processing
GO:0016310 phosphorylation
GO:0070525 tRNA threonylcarbamoyladenosine metabolic process
GO:1901796 regulation of signal transduction by p53 class mediator
Cellular Component
GO:0000408 EKC/KEOPS complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7szb, PDBe:7szb, PDBj:7szb
PDBsum7szb
PubMed
UniProtQ96S44|PRPK_HUMAN EKC/KEOPS complex subunit TP53RK (Gene Name=TP53RK)

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