Structure of PDB 7sz8 Chain A

Receptor sequence

>7sz8A (length=420) Species: 9606 (Homo sapiens)

VNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDT
PTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSV
SITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQ
LTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTA
HVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENAR
ITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKS
DTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGP
NGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDR
GSPTPLSASVEIQVTILDIN

3D structure

• PDB: 7sz8 Crystal structure of human CELSR1 EC4-7
• Chain: A
• Resolution: 2.337 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	N324 N326 D356 D358 N362 D426	N2 N4 D34 D36 N40 D88
BS02	CA	A	E341 E413 D444 V445 D447 D480	E19 E75 D106 V107 D109 D142
BS03	CA	A	E341 D411 E413 D447	E19 D73 E75 D109
BS04	CA	A	N446 N448 D478 D480 S483 D531	N108 N110 D140 D142 S145 D193
BS05	CA	A	N548 H550 D580 D582 N586 D631	N210 H212 D242 D244 N248 D293
BS06	CA	A	E565 D616 E618 D652	E227 D278 E280 D314
BS07	CA	A	E565 E618 D649 A650 D652 D685	E227 E280 D311 A312 D314 D347
BS08	CA	A	N651 N653 D683 D685 N689 D737	N313 N315 D345 D347 N351 D399

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
• GO:0098609 cell-cell adhesion

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:7sz8, PDBe:7sz8, PDBj:7sz8
• PDBsum: 7sz8
• UniProt: Q9NYQ6|CELR1_HUMAN Cadherin EGF LAG seven-pass G-type receptor 1 (Gene Name=CELSR1)