Structure of PDB 7sxh Chain A

Receptor sequence
>7sxhA (length=341) Species: 9606 (Homo sapiens) [Search protein sequence]
VTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK
VLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSKDEVYLNLVLDYVPETV
YRVARHYSRQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDP
DTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVW
SAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYEFK
FPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE
LRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR
3D structure
PDB7sxh Elucidation of the GSK3 alpha Structure Informs the Design of Novel, Paralog-Selective Inhibitors.
ChainA
Resolution2.09 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I228 V263 L266 V267 F291 F293 P294 I187 V222 L225 V226 F249 F251 P252
BS02 D1E A V70 A83 K85 D133 Y134 V135 P136 R141 L188 C199 D200 V34 A47 K49 D94 Y95 V96 P97 R102 L147 C158 D159
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7sxh, PDBe:7sxh, PDBj:7sxh
PDBsum7sxh
PubMed36812145
UniProtP49841|GSK3B_HUMAN Glycogen synthase kinase-3 beta (Gene Name=GSK3B)

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