Structure of PDB 7sxg Chain A

Receptor sequence
>7sxgA (length=334) Species: 9606 (Homo sapiens) [Search protein sequence]
VVATLGQPEREVAYTDIKVIGNGSFGVVYQARLRELVAIKKVLQDKRFKN
RELQIMRKLDHCNIVRLRYFFYSSGEELYLNLVLEYVPETVYRVARHFTK
AKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKL
CDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLA
ELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKA
HPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGT
QLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHL
3D structure
PDB7sxg Elucidation of the GSK3 alpha Structure Informs the Design of Novel, Paralog-Selective Inhibitors.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V330 I333 Y351 F354 F356 P357 V219 I222 Y240 F243 F245 P246
BS02 D1E A I125 V133 A146 K148 E196 Y197 V198 P199 R204 L251 C262 D263 I20 V28 A38 K40 E85 Y86 V87 P88 R93 L140 C151 D152
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7sxg, PDBe:7sxg, PDBj:7sxg
PDBsum7sxg
PubMed36812145
UniProtP49840|GSK3A_HUMAN Glycogen synthase kinase-3 alpha (Gene Name=GSK3A)

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