Structure of PDB 7sxe Chain A

Receptor sequence

>7sxeA (length=638) Species: 9606 (Homo sapiens) [Search protein sequence]

LDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVE
TLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLALGVGDGVLLKAVAQ
ATGRQLESVRAEAAEKGDVGLVAENSRMLPPPPLTASGVFSKFRDIARLT
GSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQ
AVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDR
IIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAFTC
EYKYDGQRAQIHALEGGEVKIFSRNQADNTGKYPDIISRIPKIKLPSVTS
FILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYL
NGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSV
KDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAY
LGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKAL
VLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSD
KGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQSQI

3D structure

PDB

7sxe Structures of LIG1 that engage with mutagenic mismatches inserted by pol beta in base excision repair.

Chain

Resolution

3.0 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

6.5.1.1: DNA ligase (ATP).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	L347 G348 G350 Q572 R573 S588 F635 F872	L87 G88 G90 Q307 R308 S323 F370 F607
BS02	dna	A	S303 Y749 T798 G799 F800 S801 D802 F872 R874	S43 Y484 T533 G534 F535 S536 D537 F607 R609
BS03	dna	A	R305 T415 G416 S417 A418 S419 T420 R451 G453 A455 Q457 S458 Q636 T639 T640 R641 R643 R768 K770 R771 G776 C794 K795 G797 S850 S852 P853 Y855 S869 L870	R45 T150 G151 S152 A153 S154 T155 R186 G188 A190 Q192 S193 Q371 T374 T375 R376 R378 R503 K505 R506 G511 C529 K530 G532 S585 S587 P588 Y590 S604 L605
BS04	AMP	A	K568 Y569 R573 E621 F660 M723 K725 W742	K303 Y304 R308 E356 F395 M458 K460 W477

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003909	DNA ligase activity
GO:0003910	DNA ligase (ATP) activity
GO:0005524	ATP binding

	Biological Process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0071897	DNA biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7sxe, PDBe:7sxe, PDBj:7sxe
PDBsum	7sxe
PubMed	35790757
UniProt	P18858\|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

[Back to BioLiP]