Structure of PDB 7sx5 Chain A

Receptor sequence

>7sx5A (length=637) Species: 9606 (Homo sapiens) [Search protein sequence]

LDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVE
TLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLALGVGDGVLLKAVAQ
ATGRQLESVRAEAAEKGDVGLVAENSRRLMLPPPPLTASGVFSKFRDIAR
LTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAAL
SQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDL
DRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAF
TCEYKYDGQRAQIHALEGGEVKIFSRNQADNTGKYPDIISRIPKIKLPSV
TSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLI
YLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQ
SVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLGVGDTLDLVVIGA
YLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKA
LVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDS
DKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQS

3D structure

PDB

7sx5 Structures of LIG1 that engage with mutagenic mismatches inserted by pol beta in base excision repair.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

6.5.1.1: DNA ligase (ATP).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	L347 G348 G350 S588 R589 N590 F635 R643 F872	L87 G88 G90 S325 R326 N327 F372 R380 F608
BS02	dna	A	S303 R589 K744 G799 S801 D802 F872 R874	S43 R326 K481 G535 S537 D538 F608 R610
BS03	dna	A	R305 G416 A418 T420 R449 R451 L452 G453 A455 Q457 S458 Q636 T639 T640 R641 K642 R643 K644 R768 K795 G797 T798 S850 S852 P853 Y855 S869 L870 F872	R45 G153 A155 T157 R186 R188 L189 G190 A192 Q194 S195 Q373 T376 T377 R378 K379 R380 K381 R504 K531 G533 T534 S586 S588 P589 Y591 S605 L606 F608
BS04	AMP	A	K568 Y569 E621 F660 E720 M723 K746	K305 Y306 E358 F397 E457 M460 K483

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003909	DNA ligase activity
GO:0003910	DNA ligase (ATP) activity
GO:0005524	ATP binding

	Biological Process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0071897	DNA biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7sx5, PDBe:7sx5, PDBj:7sx5
PDBsum	7sx5
PubMed	35790757
UniProt	P18858\|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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