Structure of PDB 7sx4 Chain A

Receptor sequence
>7sx4A (length=1383) Species: 9606 (Homo sapiens) [Search protein sequence]
INKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLY
TAEMIAKMHWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRP
LIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGV
QMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMD
LEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWR
SYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQMTTQMFHEDAAGG
WQLVAVACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEF
YLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHVYPD
LYHSQFTYFQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLI
VMSAISLQMFCFVEELDRFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVG
HMWAPVVAIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQPL
RLRIFEKFPNRPQMVKISKLPSDFTVPKIRESFMKQFIDRVFSIRARNLL
EKETAVTKILRACTRQRMLSMKRKVQEEELRENHPYFDKPLFIVGREHRF
RNFCRVVVRARFHQLYDLLGLVTYLDWVMIIVTICSCISMMFESPFRRVM
HAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYL
VSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSG
FKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRI
NVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLS
LKGWVEVRDVIIHRVGPIHGIYIHVFVFLGCMIGLTLFVGVVIANFNENK
GTALLTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFRAKMYDITQHPFFK
RTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAM
SPAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACVIVFRFFS
ICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYG
ENINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYW
ATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLS
YNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEVDLDKDKLLFK
HMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTI
EEEVAKQTIRMWLKKCLKRIRAKQQQSCSIIHS
3D structure
PDB7sx4 Structural architecture of the human NALCN channelosome.
ChainA
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 A Y260 F271 H569 I577 Y213 F224 H501 I509
BS02 Y01 A C54 H63 F540 C22 H31 F472
BS03 Y01 A F960 V964 W971 G981 F747 V751 W758 G768
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005261 monoatomic cation channel activity
GO:0005272 sodium channel activity
GO:0005515 protein binding
GO:0022840 leak channel activity
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006811 monoatomic ion transport
GO:0006814 sodium ion transport
GO:0008218 bioluminescence
GO:0032224 positive regulation of synaptic transmission, cholinergic
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0034220 monoatomic ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0060075 regulation of resting membrane potential
GO:0070588 calcium ion transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034702 monoatomic ion channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sx4, PDBe:7sx4, PDBj:7sx4
PDBsum7sx4
PubMed34929720
UniProtQ8IZF0|NALCN_HUMAN Sodium leak channel NALCN (Gene Name=NALCN)

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