Structure of PDB 7svm Chain A

Receptor sequence

>7svmA (length=852) Species: 9606 (Homo sapiens)

KLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHS
DRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYG
MYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQG
FTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREE
RRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGG
KILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMS
EIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLD
RSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIW
INIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSG
GLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDS
PLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHC
VSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTL
YGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLG
YVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDL
DRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYM
GHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLS
FLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALK
VI

3D structure

• PDB: 7svm A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells.
• Chain: A
• Resolution: 2.69 Å

Enzymatic activity

• Enzyme Commision number: 3.4.14.5: dipeptidyl-peptidase IV.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	D06	A	E275 E276 H525 Y669 Q673 V674 S755 Y756 V781 W784 Y787 Y791 V836	E229 E230 H479 Y623 Q627 V628 S709 Y710 V735 W738 Y741 Y745 V790
BS02	D06	A	K685 R688 W754 H865 S866 I867 Y876	K639 R642 W708 H819 S820 I821 Y830
BS03	D06	A	T142 L143 Y187	T96 L97 Y141
BS04	D06	A	D747 R748 R773 A894 V897	D701 R702 R727 A848 V851
BS05	D06	A	E803 Q804 Y807	E757 Q758 Y761

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0005515 protein binding
• GO:0008236 serine-type peptidase activity
• GO:0008239 dipeptidyl-peptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0006915 apoptotic process
• GO:0006955 immune response
• GO:0043069 negative regulation of programmed cell death

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:7svm, PDBe:7svm, PDBj:7svm
• PDBsum: 7svm
• PubMed: 36044633
• UniProt: Q6V1X1|DPP8_HUMAN Dipeptidyl peptidase 8 (Gene Name=DPP8)