Structure of PDB 7sva Chain A

Receptor sequence

>7svaA (length=792) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]

SNFAPRPGFGTLGTKCIVKANHFLADLPTKDLNQYDVTITPEVSSKSVNR
AIIAELVRLYKESDLGRRLPAYDGRKSLYTAGELPFTWKEFSVKIERSYK
VAIKFVARANMHHLGEFLAGKRADCPQEAVQILDIVLRELSVKRFCPVGR
SFFSPDIKTPQRLGEGLESWCGFYQSIRPTQMGLSLNIDMASAAFIEPLP
VIEFVAQLLGKDVLSKPLSDSDRVKIKKGLRGVKVEVTHRANVRRKYRVA
GLTTQPTREQHTHLPCLQVSYLPMEACKIVEGQRYTKRLNEKQITALLKV
TCQRPRDRENDILRTVQHNAYDQDPYAKEFGMNISEKLASVEARILPAPW
LKYHENGKEKDCLPQVGQWNMMNKKMINGMTVSRWACVNFSRSVQENVAR
GFCNELGQMCEVSGMEFNPEPVIPIYSARPDQVEKALKHVYHTSMNKTKG
KELELLLAILPDNNGSLYGDLKRICETELGLISQCCLTKHVFKISKQYLA
NVSLKINVKMGGRNTVLVDAISCRIPLVSDIPTIIFGADVTHPENGEESS
PSIAAVVASQDWPEVTKYAGLVCAQAHRQELIQDLYKTWQDPGTVSGGMI
RDLLISFRKATGQKPLRIIFYRAGVSEGQFYQVLLYELDAIRKACASLEP
NYQPPVTFIVVQKRHHTRLFANNHRDKNSTDRSGNILPGTVVDTKICHPT
EFDFYLCSHAGIQGTSRPAHYHVLWDENNFTADGIQSLTNNLCYTYARCT
RSVSIVPPAYYAHLAAFRARFYLEVKPLPALKENVKRVMFYC

3D structure

PDB

7sva Structural basis for RNA slicing by a plant Argonaute.

Chain

Resolution

3.26 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	I464 T471 C472 Y638 K642 Q654 C655 C656 L657 H660 Y668 N671 V672 K675 K679 R748 S798 E799 Q834 R836 H838 R840 H881 I884 Q885 R889 Y918 R920 C921 V925 S926 Y932	I294 T301 C302 Y468 K472 Q484 C485 C486 L487 H490 Y498 N501 V502 K505 K509 R578 S626 E627 Q662 R664 H666 R668 H709 I712 Q713 R717 Y746 R748 C749 V753 S754 Y760
BS02	MG	A	D709 H935	D539 H763

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0035198	miRNA binding

	Biological Process
GO:0006417	regulation of translation
GO:0009934	regulation of meristem structural organization
GO:0010072	primary shoot apical meristem specification
GO:0010586	miRNA metabolic process
GO:0031047	regulatory ncRNA-mediated gene silencing
GO:0035019	somatic stem cell population maintenance
GO:0051607	defense response to virus
GO:1902183	regulation of shoot apical meristem development

	Cellular Component
GO:0005737	cytoplasm
GO:0009536	plastid
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:7sva, PDBe:7sva, PDBj:7sva
PDBsum	7sva
PubMed	37127820
UniProt	Q9XGW1\|AGO10_ARATH Protein argonaute 10 (Gene Name=AGO10)

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