Structure of PDB 7ssk Chain A

Receptor sequence
>7sskA (length=482) Species: 9606 (Homo sapiens) [Search protein sequence]
GIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSP
MDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLS
EVFEQEIDPVMQSLGYCCGRKLEFSPQTLDPELFVECTECGRKMHQICVL
HHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFL
RRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKAL
FAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLR
TAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKP
KRLQEWFKKMLDKAVSERIVHDYKDIFKQATEDSAKELPYFEGDFWPNVL
EESILYATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLMDGRDA
FLTLARDKHLEFSSLRRAQWSTMCMLVELHTQ
3D structure
PDB7ssk Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.
ChainA
Resolution2.36 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1163 C1164 H1255 C1258 C117 C118 H145 C148
BS02 ZN A C1247 C1250 C1272 C1275 C137 C140 C162 C165
BS03 C3I A L1398 D1399 S1400 Y1414 P1440 H1451 Q1455 I1457 P1458 W1466 L288 D289 S290 Y304 P330 H341 Q345 I347 P348 W356
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7ssk, PDBe:7ssk, PDBj:7ssk
PDBsum7ssk
PubMed36302181
UniProtQ09472|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300)

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