Structure of PDB 7ss8 Chain A

Receptor sequence
>7ss8A (length=484) Species: 9606 (Homo sapiens) [Search protein sequence]
GIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSP
MDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLS
EVFEQEIDPVMQSLGYCCGRKLEFSPNDTLDPELFVECTECGRKMHQICV
LHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDF
LRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKA
LFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCL
RTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPK
PKRLQEWFKKMLDKAVSERIVHDYKDIFKQATEDRSAKELPYFEGDFWPN
VLEESILYATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLMDGR
DAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQ
3D structure
PDB7ss8 Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1163 C1164 H1255 C1258 C117 C118 H146 C149
BS02 ZN A C1247 C1250 C1272 C1275 C138 C141 C163 C166
BS03 C0C A L1398 D1399 S1400 Y1414 Y1446 H1451 Q1455 I1457 R1462 L1463 W1466 L289 D290 S291 Y305 Y337 H342 Q346 I348 R353 L354 W357
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7ss8, PDBe:7ss8, PDBj:7ss8
PDBsum7ss8
PubMed36302181
UniProtQ09472|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300)

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