Structure of PDB 7ss7 Chain A

Receptor sequence
>7ss7A (length=234) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
ATLFIADLHLQTEEPAITAGFLRFLQGEARQADALYILGDLFEAWIGDDD
PNPLHQQIASAIKAVVDAGVPCYFIHGNRDFLVGQRFARQSGMILLAEEE
RLDLYGREVLIMHGDTLCTDDQGYLAFRAKVHTPWIQRLFLALPLFIRHR
IAARMRIMDVNPQAVVDAMERHHVQWLIHGHTHRPAVHELQANGQPAWRV
VLGAWHSEGSMVKVTPDDVELIHFPFLEENLYFQ
3D structure
PDB7ss7 Development of LpxH Inhibitors Chelating the Active Site Dimanganese Metal Cluster of LpxH.
ChainA
Resolution1.73 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.54: UDP-2,3-diacylglucosamine diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D8 H10 D41 H197 Q248 D7 H9 D40 H183 Q234
BS02 MN A D41 N79 H114 H195 D40 N78 H113 H181
BS03 BN8 A H10 D41 A45 W46 N79 R80 F82 Q138 F141 M156 H195 H197 H9 D40 A44 W45 N78 R79 F81 Q137 F140 M155 H181 H183
Gene Ontology
Molecular Function
GO:0008758 UDP-2,3-diacylglucosamine hydrolase activity
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0009245 lipid A biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0019897 extrinsic component of plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ss7, PDBe:7ss7, PDBj:7ss7
PDBsum7ss7
PubMed37014664
UniProtA6T5R0|LPXH_KLEP7 UDP-2,3-diacylglucosamine hydrolase (Gene Name=lpxH)

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