Structure of PDB 7sqb Chain A

Receptor sequence
>7sqbA (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
KMQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIY
DMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYA
KSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTR
EFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGL
LNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHV
QLLQVIKKTETDMSLHPLLQEIYKDLY
3D structure
PDB7sqb PPAR gamma Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A8R A G284 C285 F287 R288 S289 I326 I341 S342 G84 C85 F87 R88 S89 I126 I141 S142
BS02 A8R A G258 I262 F264 K265 H266 R280 Q283 S342 Q345 G58 I62 F64 K65 H66 R80 Q83 S142 Q145
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sqb, PDBe:7sqb, PDBj:7sqb
PDBsum7sqb
PubMed37146157
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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