Structure of PDB 7so3 Chain A

Receptor sequence

>7so3A (length=537) Species: 11678 (Human immunodeficiency virus type 1 BH10)

MVPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKIS
KIGPENPYNTPVFAIKWRKLVDFRELNKRTQDFWEGIPHPAGLKKNKSVT
VLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFAAQNPDIVICQYMDDLYVGSDLEIGQHRTKIEELRQ
HLLRWGLTTPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLN
WASQIYPGIKVRQLSKLLRGTKALTEVIPLTEEAELELAENREILKEPVH
GVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDV
KQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWE
FVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQK
VVPLTNTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSES
ELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLV

3D structure

• PDB: 7so3 Structural Studies and Structure Activity Relationships for Novel Computationally Designed Non-nucleoside Inhibitors and Their Interactions With HIV-1 Reverse Transcriptase.
• Chain: A
• Resolution: 2.767 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	9W3	A	L100 K101 N103 V179 C181 Y183 Y188 F227 W229 L234 H235 P236 Y318	L93 K94 N96 V172 C174 Y176 Y181 F212 W214 L219 H220 P221 Y303
BS02	MG	A	D443 E478 D498	D428 E463 D483

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003964 RNA-directed DNA polymerase activity
• GO:0004523 RNA-DNA hybrid ribonuclease activity

Biological Process

• GO:0006278 RNA-templated DNA biosynthetic process

External links

• PDB: RCSB:7so3, PDBe:7so3, PDBj:7so3
• PDBsum: 7so3
• PubMed: 35237658
• UniProt: P03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)