Structure of PDB 7sme Chain A

Receptor sequence
>7smeA (length=342) Species: 9606 (Homo sapiens) [Search protein sequence]
EFTQSVSRLQSIVAGLKNAPSDQLINIFESCVRNPVENIMKILKGIGETF
CQHYTQSTDEQPGSHIDFAVNRLKLAEILYYKILETVMVQETRRLHGMDM
SVLLEQDIFHRSLMACCLEIVLFAYSSPRTFPWIIEVLNLQPFYFYKVIE
VVIRSEEGLSRDMVKHLNSIEEQILESLAWSHDSALWEALQVSANKVPTC
EEVIFRTGSLALFYRKVYHLASVRLRDLCLKLDVSNELRRKIWTCFEFTL
VHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHV
YRSVLLKSEERGDLIKFYNTIYVGRVKSFALKYDPPLSPFPH
3D structure
PDB7sme Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family.
ChainA
Resolution2.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y849 T860 F861 Q862 M865 I931 Y934 N935 V939 K943 Y271 T282 F283 Q284 M287 I315 Y318 N319 V323 K327
Gene Ontology
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:7sme, PDBe:7sme, PDBj:7sme
PDBsum7sme
PubMed35716663
UniProtP28749|RBL1_HUMAN Retinoblastoma-like protein 1 (Gene Name=RBL1)

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