Structure of PDB 7smc Chain A

Receptor sequence
>7smcA (length=340) Species: 9606 (Homo sapiens) [Search protein sequence]
EFTQSVSRLQSIVAGLKNAPSDQLINIFESCVRNPVENIMKILKGIGETF
CQHYTQSTDEQPGSHIDFAVNRLKLAEILYYKILETVMVQETRRLHGMDM
SVLLEQDIFHRSLMACCLEIVLFAYSSPRTFPWIIEVLNLQPFYFYKVIE
VVIRSEEGLSRDMVKHLNSIEEQILESLAWSHDSALWEALQVSANKVPTC
EEVIFTGSLALFYRKVYHLASVRLRDLCLKLDVSNELRRKIWTCFEFTLV
HCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVY
RSVLLKSEERGDLIKFYNTIYVGRVKSFALKYDPLSPFPH
3D structure
PDB7smc Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y849 F861 Q862 K866 R880 I931 Y934 N935 Y270 F282 Q283 K287 R301 I314 Y317 N318
Gene Ontology
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:7smc, PDBe:7smc, PDBj:7smc
PDBsum7smc
PubMed35716663
UniProtP28749|RBL1_HUMAN Retinoblastoma-like protein 1 (Gene Name=RBL1)

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