Structure of PDB 7sl7 Chain A

Receptor sequence

>7sl7A (length=819) Species: 10090 (Mus musculus)

HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD
DNEECGDVCPGTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEG
LCCHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVN
FSFCQDLHFKCRNSRCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPC
PKVCQILEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANL
GLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNL
RQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIA
LKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFYK
EAPYQNVTEFSWTVVDIDPPQRSHPGWLMRGLKPWTQYAIFVKTLVTFSD
ERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGN
ITHYLVYWERQAEDSELFELDYCLKGLKLPSRCPKTDSQILKELEESSFR
KTFEDYLHNVVFVPRPHRPFEKVVNKESLVISGLRHFTGYRIELQACNQD
SPDERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPN
GLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRVRAT
SLAGNGSWTEPTYFYVTDY

3D structure

• PDB: 7sl7 Synergistic activation of the insulin receptor via two distinct sites.
• Chain: A
• Resolution: 3.1 Å

Enzymatic activity

• Enzyme Commision number: 2.7.10.1: receptor protein-tyrosine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	D12 R14 N15 F39 K40 R65	D12 R14 N15 F39 K40 R65
BS02	peptide	A	P495 D496 F497 R539 H712 F716 V717 R719	P487 D488 F489 R522 H658 F662 V663 R665
BS03	peptide	A	R479 S481 K484 R556 G557	R471 S473 K476 R530 G531
BS04	peptide	A	D496 D709 H712 N713 F716 P718 R719	D488 D655 H658 N659 F662 P664 R665
BS05	peptide	A	R488 D535 P551 G552 W553	R480 D518 P525 G526 W527

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004713 protein tyrosine kinase activity
• GO:0004714 transmembrane receptor protein tyrosine kinase activity
• GO:0005524 ATP binding
• GO:0043548 phosphatidylinositol 3-kinase binding
• GO:0043560 insulin receptor substrate binding

Biological Process

• GO:0006468 protein phosphorylation
• GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
• GO:0046777 protein autophosphorylation

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7sl7, PDBe:7sl7, PDBj:7sl7
• PDBsum: 7sl7
• PubMed: 35361965
• UniProt: P15208|INSR_MOUSE Insulin receptor (Gene Name=Insr)