Structure of PDB 7sl4 Chain A

Receptor sequence
>7sl4A (length=786) Species: 10090 (Mus musculus) [Search protein sequence]
YPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFP
KLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLK
ELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDNC
PATFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHKECLGNCSEPDDPTK
CVACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHFKCRNSRCHQY
VIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCQIGEKTIDSVTSAQE
LRGCTVINGSLIINIRGAAELEANLGLIEEISGFLKIRRSYALVSLSFFR
KLHLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPK
LCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSFIRTSFD
KILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFSNSWTVVDIDPPQRS
HPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSV
PLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAEDSELFELDYC
LKGLKLPSRQILKELEESSFRKTFEDYLHNVVFVPRHRPFEKVVNKESLV
ISGLRHFTGYRIELQACNQDSPDERCSVAAYVSARTMPEAKADDIVGPVT
HEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALE
RGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYV
3D structure
PDB7sl4 Synergistic activation of the insulin receptor via two distinct sites.
ChainA
Resolution5.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A P495 D496 F497 R539 V715 V717 R719 P462 D463 F464 R499 V632 V634 R636
BS02 peptide A N15 L37 F39 K40 R65 N13 L35 F37 K38 R63
BS03 peptide A D496 H712 N713 F716 V717 P718 R719 D463 H629 N630 F633 V634 P635 R636
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
GO:0046777 protein autophosphorylation
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sl4, PDBe:7sl4, PDBj:7sl4
PDBsum7sl4
PubMed35361965
UniProtP15208|INSR_MOUSE Insulin receptor (Gene Name=Insr)

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