Structure of PDB 7sl2 Chain A

Receptor sequence
>7sl2A (length=806) Species: 10090 (Mus musculus) [Search protein sequence]
YPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFP
KLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLK
ELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDN
EECGDVCPGTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLC
CHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFS
FCQDLHFKCRNSRCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPK
VCQIGEKTIDSVTSAQELRGCTVINGSLIINIRGAAELEANLGLIEEISG
FLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNLRQLWDWSK
HNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQA
SCENELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVT
EFDGQSNSWTVVDIDPPQRSHPGWLMRGLKPWTQYAIFVKTLVTFSDERR
TYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITH
YLVYWERQAEDSELFELDYCLKGLKLPSRQILKELEESSFRKTFEDYLHN
VVFVPRHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPDERCSVAA
YVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSY
RRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTE
PTYFYV
3D structure
PDB7sl2 Synergistic activation of the insulin receptor via two distinct sites.
ChainA
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D496 R498 R719 D480 R482 R656
BS02 peptide A D12 R14 N15 L37 F39 K40 R65 E97 D10 R12 N13 L35 F37 K38 R63 E95
BS03 peptide A D496 D709 N713 F716 V717 P718 R719 D480 D646 N650 F653 V654 P655 R656
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
GO:0046777 protein autophosphorylation
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sl2, PDBe:7sl2, PDBj:7sl2
PDBsum7sl2
PubMed35361965
UniProtP15208|INSR_MOUSE Insulin receptor (Gene Name=Insr)

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