Structure of PDB 7sk8 Chain A

Receptor sequence
>7sk8A (length=306) Species: 9606 (Homo sapiens) [Search protein sequence]
CIVVDTVMCPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTT
GYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFS
INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCV
SLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVVLGFAVPF
SIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLD
IFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYE
LMKAFI
3D structure
PDB7sk8 Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR A W92 I126 W67 I101
BS02 CLR A C137 V140 C112 V115
BS03 CLR A K252 I253 V310 K227 I228 V285
BS04 CLR A P267 A292 A296 P242 A267 A271
BS05 CLR A C174 W208 C149 W183
BS06 GJ9 A Y51 W100 S125 L128 F129 I132 W265 Y268 Q301 S304 L305 Y26 W75 S100 L103 F104 I107 W240 Y243 Q276 S279 L280
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0005044 scavenger receptor activity
GO:0005515 protein binding
GO:0015026 coreceptor activity
GO:0016493 C-C chemokine receptor activity
GO:0016494 C-X-C chemokine receptor activity
GO:0019956 chemokine binding
GO:0019957 C-C chemokine binding
GO:0019958 C-X-C chemokine binding
Biological Process
GO:0001525 angiogenesis
GO:0001570 vasculogenesis
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0007155 cell adhesion
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008285 negative regulation of cell population proliferation
GO:0019722 calcium-mediated signaling
GO:0021557 oculomotor nerve development
GO:0031623 receptor internalization
GO:0060326 cell chemotaxis
GO:0070098 chemokine-mediated signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1905322 positive regulation of mesenchymal stem cell migration
Cellular Component
GO:0005768 endosome
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0055037 recycling endosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sk8, PDBe:7sk8, PDBj:7sk8
PDBsum7sk8
PubMed35857509
UniProtP25106|ACKR3_HUMAN Atypical chemokine receptor 3 (Gene Name=ACKR3)

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