Structure of PDB 7si7 Chain A

Receptor sequence
>7si7A (length=728) Species: 8364 (Xenopus tropicalis) [Search protein sequence]
HKEEIKQWRNSFLFSLLFGIPVIILMIYMLAATMVLDRNIVPGLSIINLV
FFILCTFVQTLGGRYFYVQAYKSLKHKATNMDVLIVLATTIAYIYSVVIL
TVAMVEKADKSPETFFDTPPMLFMFIALGRWLEHIAKSKTSEALAKLISL
QATEAAVVTFGANQIILREEQVAVELVQRGDIVKVVPGGKFPVDGKVIEG
TSMADESLITGEPMPVRKKPGSMVIAGSINAHGTVLVEATHVGSETTLAQ
IVKLVEEAQMSKAPIQQLADKISGYFVPFIIIISVVTLVTWIIIGFVNFD
IIIKYFPSYSKNISKTEVIIRVAFQTSITVLSIACPCALGLATPTAVMVG
TGVAAQNGILIKGGEPLEMAHKIKAVMFDKTGTITHGVPKVMRVLLLVKM
PLKRMLAVVGTAEASSEHPLGMAVTKYCKEELGTELLGYCTDFQAVPGCG
ISCKVNNIESVLVQHTVLIGNREWMRRNGLHISTDVDEAMSSHEMKGQTA
VLVAIDGELCGMIAIADTVKQEAALAVHTLKSMGIDVVLITGDNRKTAKA
IATQVGIKKVFAEVLPSHKVAKVQALQSDNKRVAMVGDGVNDSPALARAD
VGIAIGTGTDVAIEAADIVLIRNDLLDVVASIHLSKRTVRRIRLNFVFAL
IYNLLGIPIAAGVFMPAGLVLQPWMGSAAMAASSVSVVLSSLQLKCYRKP
DSDRYEARAQGHMKPLTPSQISVHIGMD
3D structure
PDB7si7 Structure of the Wilson disease copper transporter ATP7B.
ChainA
Resolution3.49 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.2.2.8: P-type Cu(+) transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D1024 T1026 D1273 D379 T381 D588
BS02 ALF A D1024 T1026 K1254 N1276 D1277 D379 T381 K569 N591 D592
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005507 copper ion binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity
GO:0046872 metal ion binding
GO:0140581 P-type monovalent copper transporter activity
Biological Process
GO:0006812 monoatomic cation transport
GO:0006825 copper ion transport
GO:0035434 copper ion transmembrane transport
Cellular Component
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7si7, PDBe:7si7, PDBj:7si7
PDBsum7si7
PubMed35245129
UniProtA0A6I8R0A5

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