Structure of PDB 7shq Chain A

Receptor sequence
>7shqA (length=492) Species: 9606 (Homo sapiens) [Search protein sequence]
SFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAVTGEWLDD
EVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVD
RDVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFH
LEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQG
VGDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRICESMGLAPFD
LSPRERDAVNQNQSAKTILRGTEEKCGLPRASAVALEVQRLNALDLEKKI
GKSILGKVHLAMVRYHEGGRFCEKGEEWDQESAVFHLEHAANLGELEAIV
GLGLMYSQLPHHILADVSLKETEENKTKGFDYLLKAAEAGDRQSMILVAR
AFDSGQNLSPDRCQDWLEALHWYNTALEMTEPRYMMLAREAEMLFTGGYG
LEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAWAQM
3D structure
PDB7shq Structural basis for the calmodulin-mediated activation of eukaryotic elongation factor 2 kinase.
ChainA
Resolution2.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.20: [elongation factor 2] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H260 H312 C314 C318 H183 H235 C237 C241
Gene Ontology
Molecular Function
GO:0004674 protein serine/threonine kinase activity
GO:0004686 elongation factor-2 kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7shq, PDBe:7shq, PDBj:7shq
PDBsum7shq
PubMed35857468
UniProtO00418|EF2K_HUMAN Eukaryotic elongation factor 2 kinase (Gene Name=EEF2K)

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