Structure of PDB 7sh1 Chain A

Receptor sequence

>7sh1A (length=626) Species: 324833 (Streptomyces lasalocidi)

CAADSHDMIRVHGARENNLKNVQVEIPKRRLTVFTGVSGSGKSSLVFDTI
AAESQRLINETYSAFIQLARPEVDVLDGLTTAILVDQQPMGLRSTVGTAT
DAGTLLRILFSRLAKPYIGTQKAFAFNVGGMCLACEGICSECHGTRLSET
ARSAKIDGLSIADASAMQISDLAAWIRGLTDPSVTTLLTVLGQTLESFVQ
IGLGYLSLDRSSSTLSGGEAQRVKMVRHLGSALTDVTYVFDEPTVGLHPH
DIQRMNELLLRLRDKGNTVLVVEHKPETIVIADHVVDLGPLAGTKGGEVV
FEGTVEGLRASGTVTGRHLDDRASLKPSVRQRTGVVEVRGADAHNLRDVD
VDIPLGVLTVVTGVAGSGKSSLIHGSVAGRDGVVTVDQSPIKGSRRSNPA
TYTGMLEPIRKTFAKANGVKPALFSPNSEGACPTCKGAGVIVATTCEDCG
GKRFQPSVLQYRVGGRDISEVFAMPVAEAAEFFRTGEARTPAACTVLDRL
AEVGLGYLSLGQPLTTLSGGERQRLKLAGHMGGAGSVYILDEPTSGLHLA
DVEQLLRLLDRLVDSGKTVIVVEHHQAVMAHADWIIDLGPGAGHDGGRVV
FEGTPADLVAARSTLTGEHLAQYVGA

3D structure

• PDB: 7sh1 Structural and functional analyses of the echinomycin resistance conferring protein Ecm16 from Streptomyces lasalocidi.
• Chain: A
• Resolution: 2.04 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	A	N31 N32 S52 G53 S54 G55 K56 S57 S58 Y673 L674 Q678 T682	N17 N18 S38 G39 S40 G41 K42 S43 S44 Y507 L508 Q512 T516
BS02	ADP	A	Y362 R367 H501 N502 A522 G523 G525 K526 S527 S528	Y205 R210 H344 N345 A365 G366 G368 K369 S370 S371
BS03	ZN	A	C589 C592 C612 C615	C432 C435 C446 C449
BS04	ZN	A	C176 C179 C296 C299	C132 C135 C139 C142

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0046872 metal ion binding

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7sh1, PDBe:7sh1, PDBj:7sh1
• PDBsum: 7sh1
• PubMed: 37198233
• UniProt: Q0X0A9