Structure of PDB 7sbm Chain A

Receptor sequence
>7sbmA (length=400) Species: 9606 (Homo sapiens) [Search protein sequence]
SLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQ
TTGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAK
KQSGGKVADYILAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPL
KYAIAVNDLGTEYVHRYVGKEPSGLFLNEDDKPHNPMVNAGAIVVTSLIK
QGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLK
EKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGER
VLSPEAVRNTLSLMHSCGMWDFSGQFAFHVGLPAKSGVAGGILLVVPNVM
GMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREG
3D structure
PDB7sbm High-resolution structures of mitochondrial glutaminase C tetramers indicate conformational changes upon phosphate binding.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.2: glutaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLN A Y249 Q285 S286 N335 E381 N388 Y414 W466 V484 Y110 Q144 S145 N189 E235 N242 Y268 W320 V338
Gene Ontology
Molecular Function
GO:0004359 glutaminase activity
Biological Process
GO:0006541 glutamine metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7sbm, PDBe:7sbm, PDBj:7sbm
PDBsum7sbm
PubMed34999118
UniProtO94925|GLSK_HUMAN Glutaminase kidney isoform, mitochondrial (Gene Name=GLS)

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