Structure of PDB 7s7g Chain A

Receptor sequence
>7s7gA (length=571) Species: 9606 (Homo sapiens) [Search protein sequence]
ESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELVEPVSRFFEEVND
PAKNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIVG
MHDLGVGITLGAHQSIGFKGILLFGTKAQKEKYLPKLASGETVAAFCLTE
PSSGSDAASIRTSAVPSPCGKYYTLNGSKLWISNGGLADIFTVFAKTPVT
DPATGAVKEKITAFVVERGFGGITHGPPEKKMGIKASNTAEVFFDGVRVP
SENVLGEVGSGFKVAMHILNNGRFGMAAALAGTMRGIIAKAVDHATNRTQ
FGEKIHNFGLIQEKLARMVMLQYVTESMAYMVSANMDQGATDFQIEAAIS
KIFGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDIL
RLFVALQGCMDKGKELSGLGSALKNPFGNAGGSGLSLSGLVHPELSRSGE
LAVRALEQFATVVEAKLIKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSR
ASRSLSEGHPTAQHEKMLCDTWCIEAAARIREGMAALQSDPWQQELYRNF
KSISKALVERGGVVTSNPLGF
3D structure
PDB7s7g Crystal Structure Analysis of Human VLCAD
ChainA
Resolution1.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.8.9: very-long-chain acyl-CoA dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A F174 L176 T177 G182 S183 W209 I210 S211 I417 T424 D426 I427 Q522 F146 L148 T149 G154 S155 W181 I182 S183 I389 T396 D398 I399 Q478
Gene Ontology
Molecular Function
GO:0000062 fatty-acyl-CoA binding
GO:0003995 acyl-CoA dehydrogenase activity
GO:0004466 long-chain fatty acyl-CoA dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0017099 very-long-chain fatty acyl-CoA dehydrogenase activity
GO:0042802 identical protein binding
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0001659 temperature homeostasis
GO:0006631 fatty acid metabolic process
GO:0009062 fatty acid catabolic process
GO:0009409 response to cold
GO:0015980 energy derivation by oxidation of organic compounds
GO:0030855 epithelial cell differentiation
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0046322 negative regulation of fatty acid oxidation
GO:0090181 regulation of cholesterol metabolic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0031966 mitochondrial membrane
GO:0042645 mitochondrial nucleoid

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7s7g, PDBe:7s7g, PDBj:7s7g
PDBsum7s7g
PubMed35760926
UniProtP49748|ACADV_HUMAN Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (Gene Name=ACADVL)

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