Structure of PDB 7s6m Chain A

Receptor sequence
>7s6mA (length=219) Species: 9606 (Homo sapiens) [Search protein sequence]
DKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFS
CFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAEKDKDSKLEKALKA
QNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFG
ALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFR
EISYLKKLKVKKQDRIFPP
3D structure
PDB7s6m Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A E263 I266 F267 P336 E338 E123 I126 F127 P196 E198
BS02 dna A S16 R18 A19 S20 K22 R34 F44 V48 S274 G275 S11 R13 A14 S15 K17 R29 F39 V43 S134 G135
BS03 ZN A C295 C298 C311 C321 C155 C158 C171 C181
BS04 ZN A C21 C24 H53 C56 C16 C19 H48 C51
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:7s6m, PDBe:7s6m, PDBj:7s6m
PDBsum7s6m
PubMed35793673
UniProtP09874|PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (Gene Name=PARP1)

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