Structure of PDB 7s46 Chain A

Receptor sequence
>7s46A (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
SHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAV
KKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLE
GGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRNIKSDSILLT
HDGRVKLSDFGFCAQVSKEVPRRKELVGTPYWMAPELISRLPYGPEVDIW
SLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFL
DRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR
3D structure
PDB7s46 Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4)
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A S331 Q358 R359 T404 N440 K442 D444 F461 L475 V476 G477 T478 P479 Y480 E512 F516 N517 E518 P519 M524 S32 Q59 R60 T105 N141 K143 D145 F162 L176 V177 G178 T179 P180 Y181 E213 F217 N218 E219 P220 M225
BS02 ANP A I327 V335 F397 L398 L447 I28 V36 F98 L99 L148
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7s46, PDBe:7s46, PDBj:7s46
PDBsum7s46
PubMed
UniProtO96013|PAK4_HUMAN Serine/threonine-protein kinase PAK 4 (Gene Name=PAK4)

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