Structure of PDB 7s3f Chain A

Receptor sequence
>7s3fA (length=409) Species: 9606 (Homo sapiens) [Search protein sequence]
MNNFEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKH
LRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLG
VPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLV
LRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGC
TDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEIT
GVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKSEQT
FMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGL
DRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPA
WQLMQQFQN
3D structure
PDB7s3f Structural basis of binding and inhibition of ornithine decarboxylase by 1-amino-oxy-3-aminopropane.
ChainA
Resolution2.49 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.17: ornithine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A K69 H197 S200 G237 E274 G276 R277 Y389 K67 H195 S198 G235 E272 G274 R275 Y376
BS02 XAP A L166 D332 L164 D319
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004586 ornithine decarboxylase activity
GO:0005515 protein binding
GO:0016831 carboxy-lyase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0001822 kidney development
GO:0006595 polyamine metabolic process
GO:0006596 polyamine biosynthetic process
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0009615 response to virus
GO:0033387 putrescine biosynthetic process from ornithine
GO:0042176 regulation of protein catabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7s3f, PDBe:7s3f, PDBj:7s3f
PDBsum7s3f
PubMed34796899
UniProtP11926|DCOR_HUMAN Ornithine decarboxylase (Gene Name=ODC1)

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