Structure of PDB 7s2k Chain A

Receptor sequence
>7s2kA (length=268) Species: 77133 (uncultured bacterium) [Search protein sequence]
SLIIFGIVNITSDSFSDGGRYLAPDAAIAQARKLMAEGADVIDLGPASSN
PDAAPVSSDTEIARIAPVLDALKADGIPVSLDSYQPATQAYALSRGVAYL
NDIRGFPDAAFYPQLAKSSAKLVVMHSVQDGQADRREAPAGDIMDHIAAF
FDARIAALTGAGIKRNRLVLDPGMGFFLGAAPETSLSVLARFDELRLRFD
LPVLLSVSRKSFLRALTGRGPGDVGAATLAAELAAAAGGADFIRTHEPRP
LRDGLAVLAALKETARIR
3D structure
PDB7s2k Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics.
ChainA
Resolution1.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.15: dihydropteroate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 78H A F18 S52 N53 D85 N104 I106 M128 D174 G178 F179 F180 S209 K213 S214 R247 F15 S49 N50 D82 N101 I103 M125 D171 G175 F176 F177 S206 K210 S211 R244
BS02 POP A N12 S17 F18 S51 S52 N53 R247 H249 N9 S14 F15 S48 S49 N50 R244 H246
Gene Ontology
Molecular Function
GO:0004156 dihydropteroate synthase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0042558 pteridine-containing compound metabolic process
GO:0044237 cellular metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046656 folic acid biosynthetic process
GO:0046677 response to antibiotic
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7s2k, PDBe:7s2k, PDBj:7s2k
PDBsum7s2k
PubMed37419898
UniProtP0AC11|DHP2_ECOLX Dihydropteroate synthase type-2 (Gene Name=sulII)

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