Structure of PDB 7s05 Chain A

Receptor sequence
>7s05A (length=437) Species: 9606 (Homo sapiens) [Search protein sequence]
YHVLFDSYRDNIAGKSFQNRLCLPMPIDVVYTWVNGTDLELLKELQQVRE
QMEEEQKAMREILFEDNEELRYSLRSIERHAPWVRNIFIVTNGQIPSWLN
LDNPRVTIVTHQDVFRNLSHLPTFSSPAIESHIHRIEGLSQKFIYLNDDV
MFGKDVWPDDFYSHSKGQKVYLTWPVTFADSLRYVNKILNSKFGFTSRKV
PAHMPHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMS
AVQPLNISQVFDEVDTDQSGVLSDREIRTLATRIHELPLSLQDLTGLEHM
LINCSKMLESYYDPNLPPVTKSLVTNCKPVTDKIHKAYKDKNKYRFEIMG
EEEIAFKMIRTNVSHVVGQLDDIRKNPRKFVCLNDNIDHNHKDAQTVKAV
LRDFYESMFPIPSQFELPREYRNRFLHMHELQEWRAY
3D structure
PDB7s05 Structure of the human GlcNAc-1-phosphotransferase alpha beta subunits reveals regulatory mechanism for lysosomal enzyme glycan phosphorylation.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.8.17: UDP-N-acetylglucosamine--lysosomal-enzyme N-acetylglucosaminephosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D1018 D1020 V1024 E1029 D265 D267 V271 E276
Gene Ontology
Molecular Function
GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0007040 lysosome organization
GO:0009306 protein secretion
GO:0016256 N-glycan processing to lysosome
GO:0033299 secretion of lysosomal enzymes
GO:0046835 carbohydrate phosphorylation
GO:0051649 establishment of localization in cell
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7s05, PDBe:7s05, PDBj:7s05
PDBsum7s05
PubMed35332324
UniProtQ3T906|GNPTA_HUMAN N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (Gene Name=GNPTAB)

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