Structure of PDB 7s04 Chain A

Receptor sequence
>7s04A (length=396) Species: 470 (Acinetobacter baumannii) [Search protein sequence]
TQSVCILGVTGSIGRSTLKILGQHPDKYSVFAVSAHSRISELVEICKQFR
PKVVVVPEQKIAELKTLFAQQNISDIDVLAGQEGLVDIASHTDVDIVMAA
IVGAAGLLPTLAAVKAGKRVLLANKEALVMSGEIMMQAARDHQALLLPVD
SEHNAIFQSLPHNYLQADRTGQPQLGVSKILLTASGGPFLNHSLEQLVHV
TPQQACKHPNWSMGQKISVDSATLMNKGLELIEACHLFSISEHFVTVVVH
PQSIIHSMVQYVDGSTLAQMGNPDMCTPIAHALAWPERLQTNVPALDLFE
YSQLNFQAPDTQKFPALNLARQAMRAGGLAPTILNAANEIAVEAFLMERI
GFTSIPQVVEHTLEKLENAAAESIECILDKDKVARSVAQQYISSIG
3D structure
PDB7s04 Characterization and Inhibition of 1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase: A Promising Drug Target in Acinetobacter baumannii and Klebsiella pneumoniae .
ChainA
Resolution2.52 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.1.1.267: 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0030145 manganese ion binding
GO:0030604 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GO:0046872 metal ion binding
GO:0070402 NADPH binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
GO:0051484 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7s04, PDBe:7s04, PDBj:7s04
PDBsum7s04
PubMed34672535
UniProtB7H1U5|DXR_ACIB3 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Gene Name=dxr)

[Back to BioLiP]