Structure of PDB 7rzz Chain A

Receptor sequence

>7rzzA (length=394) Species: 6239 (Caenorhabditis elegans)

LPTWSLMRSRLSLSEVLDSGDLMKFAVDKTGCQFLEKAVKGSLTSYQKFQ
LFEQVIGRKDDFLKLSTNIFGNYLVQSVIGISLATNDDGYTKRQEKLKNF
ISSQMTDMCLDKFACRVIQSSLQNMDLSLACKLVQALPRDARLIAICVDQ
NANHVIQKVVAVIPLKNWEFIVDFVATPEHLRQICSDKYGCRVVQTIIEK
LTADSMNVDLTSAAQNLRERALQRLMTSVTNRCQELATNEYANYIIQHIV
SNDDLAVYRECIIEKCLMRNLLSLSQEKFASHVVEKAFLHAPLELLAEMM
DEIFDGYIPHPDTGKDALDIMMFHQFGNYVVQCMLTICCDAVSGRRQTKE
GGYDHAISFQDWLKKLHSRVTKERHRLSRFSSGKKMIETLANLR

3D structure

• PDB: 7rzz Bipartite interaction sites differentially modulate RNA-binding affinity of a protein complex essential for germline stem cell self-renewal.
• Chain: A
• Resolution: 2.39 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	N244 Y245 F285 R288 Q291 Q322 N323 H326 Q329 K360 Y361 R364 Q367 Y413 N415 Y416 Q419 K450 S453 H454 E457 F495 F498 N500 Y501 Q504 F552 S553 S554 K557	N72 Y73 F113 R116 Q119 Q150 N151 H154 Q157 K188 Y189 R192 Q195 Y241 N243 Y244 Q247 K278 S281 H282 E285 F323 F326 N328 Y329 Q332 F380 S381 S382 K385
BS02	peptide	A	R441 L444 S445 Q448 E449 G478 Y479 I480 K487 D488 A489 I492	R269 L272 S273 Q276 E277 G306 Y307 I308 K315 D316 A317 I320

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

External links

• PDB: RCSB:7rzz, PDBe:7rzz, PDBj:7rzz
• PDBsum: 7rzz
• PubMed: 34908132
• UniProt: Q09312|FBF2_CAEEL Fem-3 mRNA-binding factor 2 (Gene Name=fbf-2)