Structure of PDB 7ry1 Chain A

Receptor sequence
>7ry1A (length=405) Species: 9606 (Homo sapiens) [Search protein sequence]
TKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF
VPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSE
DLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFS
KNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIY
YITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLV
SVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRL
VTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYAKKHLEINPDHSIIE
TLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKL
GLGID
3D structure
PDB7ry1 Crystal structure of the middle and C-terminal domains of Hsp90 alpha labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target.
ChainA
Resolution3.523 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.10: non-chaperonin molecular chaperone ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MDC A M371 C374 E375 E376 Q405 L409 M79 C82 E83 E84 Q113 L117
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding

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Molecular Function
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Biological Process
External links
PDB RCSB:7ry1, PDBe:7ry1, PDBj:7ry1
PDBsum7ry1
PubMed35503206
UniProtP07900|HS90A_HUMAN Heat shock protein HSP 90-alpha (Gene Name=HSP90AA1)

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