Structure of PDB 7rxg Chain A

Receptor sequence

>7rxgA (length=650) Species: 451804 (Aspergillus fumigatus A1163) [Search protein sequence]

ENHHVDYVIRFNYGDIDTPEAIKKFEVLLLELSEVGLQTEVRQGDENSLF
VFVRAASKKKLKRAVYQSRVRDWLYGVRNTEPEPASSAKPQSEAERLLVI
YHLITVPKAEGGAGITPRHGEWKNVDAIFPLHDEETNRQCMREWSKKTFL
STEDLDRIRNTFGEHVGFYFAFLQSYFRFLMFPAAFGFSCWLLLGSFSII
YTVVNCLWCIVFIEYWKRQEEDLSCRWQTKGVSAVHEKRAEFKPEKEIRD
ESTGEVRGVFPATKRMYRQLLQVPFALLAAVALGAIIATCFAIEIFISEV
YNGPLKGYLVFIPTILVSALIPTMSAVLLTVATKLNDYENYETQDAYKVA
LTQKIFVVNFITSYLPIILTAFVYVPFASRIVPYLDVFHLTVRPFVSKEH
AIKARTEFSINPDRLRKQVIYFTVTAQIVGFALETIVPFVKQRVFREYKE
YTDEDEARFLTRVRNEAELEDYDVTDDLREMCIQFGYLALFSPVWPLVPV
SFLINNWVELRSDFFKICVECKRPWPQRADTIGPWLDSLGFLSWVGSITS
SALVYMFSNGHEGPNGEPTTIRCWALLLTIFFSEHLYLIVRYAVRSALAK
LEPPNTRRERIERFMMRKRYLDTVLSPTERFWMRQRGWKESAEVGLSLIT

3D structure

PDB

7rxg TMEM16 scramblases thin the membrane to enable lipid scrambling.

Chain

Resolution

2.28 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	PGW	A	A287 Q364	A276 Q353
BS02	PGW	A	H619 I623 Y626	H585 I589 Y592
BS03	PGW	A	F367 V368 G574 F575 W578 R625	F356 V357 G540 F541 W544 R591
BS04	CA	A	E445 D511 E514 E543 D547	E434 D477 E480 E509 D513
BS05	CA	A	E445 E514 E543	E434 E480 E509
BS06	PGW	A	T213 L218 Y589 S592 T604 R606 T613 F616 S617 L620 Y621	T202 L207 Y555 S558 T570 R572 T579 F582 S583 L586 Y587
BS07	PGW	A	F388 R391 I392 Y395	F377 R380 I381 Y384
BS08	PGW	A	F371 F383 F388 T583 I605	F360 F372 F377 T549 I571
BS09	PGW	A	W202 W529 L531 S535 N539	W191 W495 L497 S501 N505
BS10	PGW	A	F208 S209 I210 I211	F197 S198 I199 I200
BS11	PGW	A	F160 M192 A196 F197 S200	F149 M181 A185 F186 S189
BS12	PGW	A	R189 F190 F193 W219 Y226	R178 F179 F182 W208 Y215
BS13	PGW	A	Y626 A627 S630	Y592 A593 S596

Gene Ontology

	Molecular Function
GO:0005245	voltage-gated calcium channel activity
GO:0005254	chloride channel activity
GO:0017128	phospholipid scramblase activity

	Biological Process
GO:0017121	plasma membrane phospholipid scrambling
GO:0034220	monoatomic ion transmembrane transport
GO:0045332	phospholipid translocation
GO:0070588	calcium ion transmembrane transport
GO:1902476	chloride transmembrane transport

	Cellular Component
GO:0016020	membrane
GO:0032541	cortical endoplasmic reticulum

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7rxg, PDBe:7rxg, PDBj:7rxg
PDBsum	7rxg
PubMed	35562175
UniProt	Q4WA18

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