Structure of PDB 7rxa Chain A

Receptor sequence
>7rxaA (length=578) Species: 451804 (Aspergillus fumigatus A1163) [Search protein sequence]
QENHHVDYVIRFNYGDIDTPEAIKKFEVLLLELSEVGLQTEVRQGDENSL
FVFVRAASKKKLKRAVYQSRVRDWLYGVRNTEPEQSEAERLLVIYHLITV
PKAEGGAGITPRHGEWKNVDAIFPLHDEETNRQCMREWSKKTFLSTEDLD
RIRNTFGEHVGFYFAFLQSYFRFLMFPAAFGFSCWLLLGSFSIIYTVVNC
LWCIVFIEYWKRQEEDLSCRWQTKGVSAVHEKRAEFKPEKERGVFPATKR
MYRQLLQVPFALLAAVALGAIIATCFAIEIFISEVYKGYLVFIPTILVSA
LIPTMSAVLLTVATKLNDYENYETQDAYKVALTQKIFVVNFITSYLPIIL
TAFVYVPFASRIVPYLDVINPDRLRKQVIYFTVTAQIVGFALETDEARFL
TRVRNEAELEDYDVTDALRAMCIQFGYLALFSPVWPLVPVSFLINNWVEL
RSDFFKICVECKRPWPQRADTIGPWLDSLGFLSWVGSITSSALVYMFSNT
IRCWALLLTIFFSEHLYLIVRYAVRSALAKLEPPNTRRERIERFMMRKRY
LDTVLTERFWMRQRGWKESAEVGLSLIT
3D structure
PDB7rxa TMEM16 scramblases thin the membrane to enable lipid scrambling.
ChainA
Resolution3.08 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PGW A V214 C217 S585 Y589 S592 T613 V197 C200 S491 Y495 S498 T509
BS02 PGW A Y626 K634 Y522 K530
BS03 PGW A F616 H619 I623 Y626 F512 H515 I519 Y522
BS04 PGW A F367 F575 F337 F481
Gene Ontology
Molecular Function
GO:0005245 voltage-gated calcium channel activity
GO:0005254 chloride channel activity
GO:0017128 phospholipid scramblase activity
Biological Process
GO:0017121 plasma membrane phospholipid scrambling
GO:0034220 monoatomic ion transmembrane transport
GO:0045332 phospholipid translocation
GO:0070588 calcium ion transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0032541 cortical endoplasmic reticulum

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7rxa, PDBe:7rxa, PDBj:7rxa
PDBsum7rxa
PubMed35562175
UniProtQ4WA18

[Back to BioLiP]