Structure of PDB 7rwj Chain A

Receptor sequence
>7rwjA (length=606) Species: 330879 (Aspergillus fumigatus Af293) [Search protein sequence]
NHHVDYVIRFNYGDIDTPEAIKKFEVLLLELSEVGLQTEVRQGDENSLFV
FVRAASKKKLKRAVYQSRVRDWLYGVRNTEPEPASSAKPQSEAERLLVIY
HLITVPKAEGGAGITPRHGEWKNVDAIFPLHDEETNRQCMREWSKKTFLS
TEDLDRIRNTFGEHVGFYFAFLQSYFRFLMFPAAFGFSCWLLLGSFSIIY
TVVNCLWCIVFIEYWKRQEEDLSCRWQTKGVSAVHEKRAEFKPEKEIRVR
GVFPATKRMYRQLLQVPFALLAAVALGAIIATCFAIEIFISEVYKGYLVF
IPTILVSALIPTMSAVLLTVATKLNDYENYETQDAYKVALTQKIFVVNFI
TSYLPIILTAFVYVPFASRIVPYLFSINPDRLRKQVIYFTVTAQIVGFAL
ETIVPFVKQEDEARFLTRVRNEAELEDYDVTDDLREMCIQFGYLALFSPV
WPLVPVSFLINNWVELRSDFFKICVECKRPWPQRADTIGPWLDSLGFLSW
VGSITSSALVYMFSNGHEGPNGEPTTIRCWALLLTIFFSEHLYLIVRYAV
RSALAKLEPPNTRRERIERFMMRKRYLDTVLSPTERFWMRQRGWKESAEV
GLSLIT
3D structure
PDB7rwj TMEM16 scramblases thin the membrane to enable lipid scrambling.
ChainA
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PGW A F367 V368 F575 W578 F345 V346 F497 W500
BS02 CA A E445 D511 E514 E543 D547 E401 D433 E436 E465 D469
BS03 CA A N539 E543 N461 E465
BS04 PGW A V214 C217 V588 Y589 T613 V202 C205 V510 Y511 T535
BS05 PGW A Y626 R629 Y548 R551
Gene Ontology
Molecular Function
GO:0005245 voltage-gated calcium channel activity
GO:0005254 chloride channel activity
GO:0017128 phospholipid scramblase activity
Biological Process
GO:0017121 plasma membrane phospholipid scrambling
GO:0034220 monoatomic ion transmembrane transport
GO:0045332 phospholipid translocation
GO:0070588 calcium ion transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0032541 cortical endoplasmic reticulum

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7rwj, PDBe:7rwj, PDBj:7rwj
PDBsum7rwj
PubMed35562175
UniProtQ4WA18

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