Structure of PDB 7rue Chain A

Receptor sequence
>7rueA (length=339) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
NDDLRIKEIKELLPPVALLEKFPATENAANTVAHARKAIHKILKGNDDRL
LVVIGPCSIHDPVAAKEYATRLLALREELKDELEIVMRVYFEKPRTTVGW
KGLINDPHMDNSFQINDGLRIARKLLLDINDSGLPAAGEFLDMITPQYLA
DLMSWGAIGARTTESQVHRELASGLSCPVGFKNGTDGTIKVAIDAINAAG
APHCFLSVTKWGHSAIVNTSGNGDCHIILRGGKEPNYSAKHVAEVKEGLN
KAGLPAQVMIDFSHANSSQFKKQMDVCADVCQQIAGGEKAIIGVMVESHL
VEGNQSLLAYGKSITDACIGWEDTDALLRQLANAVKARR
3D structure
PDB7rue An Inhibitor-in-Pieces Approach to DAHP Synthase Inhibition: Potent Enzyme and Bacterial Growth Inhibition.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7QH A R92 Y94 G163 A164 K186 R234 H268 R88 Y90 G159 A160 K182 R230 H264
BS02 MN A C61 H268 E302 D326 C57 H264 E297 D316
Gene Ontology
Molecular Function
GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity
GO:0016740 transferase activity
GO:0042802 identical protein binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009058 biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:7rue, PDBe:7rue, PDBj:7rue
PDBsum7rue
PubMed34761906
UniProtP0AB91|AROG_ECOLI Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive (Gene Name=aroG)

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