Structure of PDB 7rtk Chain A

Receptor sequence
>7rtkA (length=395) Species: 9606 (Homo sapiens) [Search protein sequence]
SLRPLYMDVQATTPLDPRVLDAMLPYLINYYGNPHSRTHAYGWESEAAME
RARQQVASLIGADPREIIFTSGATESNNIAIKGVARFYRSRKKHLITTQT
EHKCVLDSCRSLEAEGFQVTYLPVQKSGIIDLKELEAAIQPDTSLVSVMT
VNNEIGVKQPIAEIGRICSSRKVYFHTDAAQAVGKIPLDVNDMKIDLMSI
SGHKIYGPKGVGAIYIRRRPRVRVEALQSGGGQERGMRSGTVPTPLVVGL
GAACEVAQQEMEYDHKRISKLSERLIQNIMKSLPDVVMNGDPKHHYPGCI
NLSFAYVEGESLLMALKDVALSSGSACPSYVLRAIGTDEDLAHSSIRFGI
GRFTTEEEVDYTVEKCIQHVKRLREMSPLWEMVQDGIDLKSIKWT
3D structure
PDB7rtk The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.8.1.7: cysteine desulfurase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A G126 A127 T128 H156 D232 A234 Q235 S255 H257 K258 C381 G72 A73 T74 H102 D178 A180 Q181 S201 H203 K204 C327
Gene Ontology
Molecular Function
GO:0030170 pyridoxal phosphate binding
GO:0031071 cysteine desulfurase activity
Biological Process
GO:0044571 [2Fe-2S] cluster assembly

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Molecular Function
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Biological Process
External links
PDB RCSB:7rtk, PDBe:7rtk, PDBj:7rtk
PDBsum7rtk
PubMed
UniProtQ9Y697|NFS1_HUMAN Cysteine desulfurase (Gene Name=NFS1)

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