Structure of PDB 7rt3 Chain A

Receptor sequence
>7rt3A (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
TEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETS
LLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQIK
RVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQG
VDDAFYTLVREIRKHKEK
3D structure
PDB7rt3 Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS G12D Inhibitor.
ChainA
Resolution1.56 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G13 V14 G15 K16 S17 A18 F28 E31 N116 K117 D119 S145 A146 K147 G12 V13 G14 K15 S16 A17 F27 E30 N115 K116 D118 S144 A145 K146
BS02 7NZ A D12 G60 E62 Y64 R68 D69 M72 H95 Y96 Q99 I100 D11 G59 E61 Y63 R67 D68 M71 H94 Y95 Q98 I99
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:7rt3, PDBe:7rt3, PDBj:7rt3
PDBsum7rt3
PubMed34889605
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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