Structure of PDB 7rrx Chain A

Receptor sequence
>7rrxA (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVH
MINWAKRVPGFVDLTSHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAP
NLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNS
GVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQ
LLLILSHIRHMSNKGMEHLYSVVPSYDLLLEMLDA
3D structure
PDB7rrx Dual-mechanism estrogen receptor inhibitors.
ChainA
Resolution1.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7AI A L346 T347 A350 E353 M388 E419 G420 M421 I424 F425 L428 H524 L525 V533 L40 T41 A44 E47 M82 E113 G114 M115 I118 F119 L122 H218 L219 V222
External links
PDB RCSB:7rrx, PDBe:7rrx, PDBj:7rrx
PDBsum7rrx
PubMed34452998
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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